Who we are

Systems neuroscience examines the principles of brain function across different levels of organisation, from neurons to circuits, networks and people. Likewise, clinical disorders can occur at any of these scales - from disorders of synaptic plasticity through to the social determinants of health.

The Systems Neuroscience group employs a variety of computational and observational tools - mathematical models, advanced statistics, imaging and behavioural observations.

Our team is culturally diverse and multidisciplinary, bringing together mathematicians, neuroscientists, psychologists, clinicians, social scientists and physicists to solve important fundamental and clinical questions.

Our research projects

  • Bringing together Australia’s leading researchers, clinicians and consumers to create a powerful network for dementia prevention, treatment and care.

    Visit the study website

  • The Prospective Imaging Study of Ageing (PISA): Genes, Brain and Behaviour studies the interplay between genetic, epigenetic and environmental factors for dementia, and also aims to identify risk factors that could be modified through intervention – such as lifestyle choices.

  • Cognitive control allows us to amplify salient features of the environment, something that people with psychosis often find challenging. This study combines computational modelling and brain imaging to identify the processes underlying this important clinical issue.

  • Is emotion really as simple as smiling when you’re happy, and frowning when you’re angry?

  • This research is looking at the interplay of sleep, cognitive abilities, brain structure and neural activity in older adults both with and without a genetic risk of developing dementia.

  • Many adults experience hearing loss later in life, which can affect their quality of life. Cochlear implants are a promising way to address this issue. We are using brain imaging to measure changes in brain function and structure after cochlear implant surgery.

    Learn more

Meet the team

Our recent publications

Amyloid induced hyperexcitability in default mode network drives medial temporal hyperactivity and early tau accumulation

Neuron (2023): 112,1–11

Joseph Giorgio, Jenna N. Adams, Anne Maass, William J. Jagust, Michael Breakspear

Read more Download PDF

Cognitive control system gates insula processing of affective stimuli in early psychosis

Schizophrenia Bulletin (2023)

Nikitas C Koussis, Bjorn Burgher, Jayson Jeganathan, James G Scott, Luca Cocchi & Michael Breakspear

Read more Download PDF

Quantifying dynamic facial expressions under naturalistic conditions

eLife Computational and Systems Biology (2022)

Jayson Jeganathan, Megan Campbell, Matthew Hyett, Gordon Parker & Michael Breakspear

Read more Download PDF

Functional re-organization of hippocampal-cortical gradients during naturalistic memory processes

NeuroImage 271 (2023)

Léonie Borne, Ye Tian, Michelle K Lupton, Johan N van der Meer, Jayson Jeganathan, Bryan Paton, Nikitas Koussis, Christine C Guo, Gail A Robinson, Jurgen Fripp, Andrew Zalesky & Michael Breakspear

Read more Download PDF

Geometric constraints on human brain function

Nature (2023): 618, 566-574

James Pang, Kevin Aquino, Marianna Oldehinnkel, Peter Robinson, Ben Fulcher, Michael Breakspear & Alex Fornito

Read more

Mechanisms of imbalanced frontostriatal functional connectivity in obsessive-compulsive disorder

Brain (2023): 146 (4), 1322-1327

Sebastian Naze, Luke Hearne, …, Andrew Zalesky, Michael Breakspear & Luca Cocchi

Read more Download PDF

Contact us

Want to collaborate? Get in touch. We’d love to hear from you.

Our group is located at the Hunter Medical Research Institute (HMRI) in Newcastle.